Ontology highlight
ABSTRACT:
SUBMITTER: Johannessen A
PROVIDER: S-EPMC9810658 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Johannessen Asgeir A Stockdale Alexander J AJ Henrion Marc Y R MYR Okeke Edith E Seydi Moussa M Wandeler Gilles G Sonderup Mark M Spearman C Wendy CW Vinikoor Michael M Sinkala Edford E Desalegn Hailemichael H Fall Fatou F Riches Nicholas N Davwar Pantong P Duguru Mary M Maponga Tongai T Taljaard Jantjie J Matthews Philippa C PC Andersson Monique M Mboup Souleyman S Sombie Roger R Shimakawa Yusuke Y Lemoine Maud M
Nature communications 20230103 1
In sub-Saharan Africa, simple biomarkers of liver fibrosis are needed to scale-up hepatitis B treatment. We conducted an individual participant data meta-analysis of 3,548 chronic hepatitis B patients living in eight sub-Saharan African countries to assess the World Health Organization-recommended aspartate aminotransferase-to-platelet ratio index and two other fibrosis biomarkers using a Bayesian bivariate model. Transient elastography was used as a reference test with liver stiffness measureme ...[more]