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Auxin promotes hypocotyl elongation by enhancing BZR1 nuclear accumulation in Arabidopsis.


ABSTRACT: Auxin and brassinosteroids (BRs) are two major growth-promoting phytohormones that shape hypocotyl elongation; however, the cross-talk between auxin and BR in this process is not fully understood. In this study, we found that auxin-induced hypocotyl elongation is dependent on brassinazole-resistant 1 (BZR1), a core BR signaling component. Auxin promotes BZR1 nuclear accumulation in hypocotyl cells, a process dependent on mitogen-activated protein kinase 3 (MPK3) and MPK6, which are both activated by auxin and whose encoding genes are highly expressed in hypocotyls. We determined that MPK3/MPK6 phosphorylate and reduce the protein stability of general regulatory factor 4 (GRF4), a member of the 14-3-3 family of proteins that retain BZR1 in the cytoplasm. In summary, this study reveals the molecular mechanism by which auxin promotes hypocotyl elongation by enhancing BZR1 nuclear accumulation via MPK3/MPK6-regulated GRF4 protein stability.

SUBMITTER: Yu Z 

PROVIDER: S-EPMC9812374 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Auxin promotes hypocotyl elongation by enhancing BZR1 nuclear accumulation in <i>Arabidopsis</i>.

Yu Zipeng Z   Ma Jinxin J   Zhang Mengyue M   Li Xiaoxuan X   Sun Yi Y   Zhang Mengxin M   Ding Zhaojun Z  

Science advances 20230104 1


Auxin and brassinosteroids (BRs) are two major growth-promoting phytohormones that shape hypocotyl elongation; however, the cross-talk between auxin and BR in this process is not fully understood. In this study, we found that auxin-induced hypocotyl elongation is dependent on brassinazole-resistant 1 (BZR1), a core BR signaling component. Auxin promotes BZR1 nuclear accumulation in hypocotyl cells, a process dependent on mitogen-activated protein kinase 3 (MPK3) and MPK6, which are both activate  ...[more]

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