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Melanin nanoparticles alleviate sepsis-induced myocardial injury by suppressing ferroptosis and inflammation.


ABSTRACT: Myocardial injury as one of the severe complications leads to the increasing morbidity and mortality in patients with sepsis. Recent studies reported that reactive oxygen species (ROS)-mediated ferroptosis plays a critical role in the development of heart diseases. Therefore, we hypothesized that anti-ferroptosis agent might be a novel potential therapeutic strategy for sepsis-induced cardiac injury. Herein, we demonstrated that a small biocompatible and MRI-visible melanin nanoparticles (MMPP) improves myocardial function by inhibiting ROS-related ferroptosis signaling pathway. In LPS-induced murine sepsis model, after a single dose intravenously injection of MMPP treatment, MMPP markedly alleviated the myocardial injury including cardiac function and heart structure disorder through suppressing iron-accumulation induced ferroptosis. In vitro, MMPP inhibited cardiomyocyte death by attenuating oxidative stress, inflammation and maintaining mitochondrial homeostasis. Collectively, our findings demonstrated that MMPP protected heart against sepsis-induced myocardial injury via inhibiting ferroptosis and inflammation, which might be a novel therapeutic approach in future.

SUBMITTER: Liu C 

PROVIDER: S-EPMC9813528 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature

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Melanin nanoparticles alleviate sepsis-induced myocardial injury by suppressing ferroptosis and inflammation.

Liu Chang C   Zou Quan Q   Tang Huixin H   Liu Jia J   Zhang Shiqi S   Fan Caihong C   Zhang Junwei J   Liu Ruiqing R   Liu Yashan Y   Liu Ruiyan R   Zhao Yan Y   Wu Qiang Q   Qi Zhi Z   Shen Yanna Y  

Bioactive materials 20221227


Myocardial injury as one of the severe complications leads to the increasing morbidity and mortality in patients with sepsis. Recent studies reported that reactive oxygen species (ROS)-mediated ferroptosis plays a critical role in the development of heart diseases. Therefore, we hypothesized that anti-ferroptosis agent might be a novel potential therapeutic strategy for sepsis-induced cardiac injury. Herein, we demonstrated that a small biocompatible and MRI-visible melanin nanoparticles (MMPP)  ...[more]

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