Dataset Information

Effect on bone anabolic markers of daily cheese intake with and without vitamin K₂: a randomised clinical trial.

ABSTRACT:

Background

Daily intake of 57 g Jarlsberg cheese has been shown to increase the total serum osteocalcin (tOC). Is this a general cheese effect or specific for Jarlsberg containing vitamin K₂ and 1,4-dihydroxy-2naphtoic acid (DHNA)?

Methods

66 healthy female volunteers (HV) were recruited. By skewed randomisation (3:2), 41 HV were allocated to daily intake of 57 g Jarlsberg (J-group) and 25-50 g Camembert (C-group) in 6 weeks. After 6 weeks the C-group was switched to Jarlsberg. The study duration was 12 weeks with clinical investigations every 6 weeks. The main variables were procollagen type 1 N-terminal propeptide (PINP), tOC, carboxylated osteocalcin (cOC) and the osteocalcin ratio (R_O) defined as the ratio between cOC and undercarboxylated osteocalcin (ucOC). Serum cross-linked C-telopeptide type I collagen (CTX), vitamin K₂, lipids and clinical chemistry were used as secondary variables.

Results

PINP, tOC, cOC, R_O and vitamin K₂ increased significantly (p<0.01) after 6 weeks in the J-group. PINP remained unchanged in the C-group. The other variables decreased slightly in the C-group but increased significantly (p≤0.05) after switching to Jarlsberg. No CTX-changes detected in neither of the groups.Serum lipids increased slightly in both groups. Switching to Jarlsberg, total cholesterol and low-density lipoprotein-cholesterol were significantly reduced (p≤0.05). Glycated haemoglobin (HbA1c), Ca⁺⁺ and Mg⁺⁺ were significantly reduced in the J-group, but unchanged in the C-group. Switching to Jarlsberg, HbA1c and Ca⁺⁺ decreased significantly.

Conclusion

The effect of daily Jarlsberg intake on increased s-osteocalcin level is not a general cheese effect. Jarlsberg contain vitamin K₂ and DHNA which increases PINP, tOC, cOC and R_O and decreases Ca⁺⁺, Mg⁺⁺ and HbA1c. These effects reflect increased bone anabolism and a possible reduced risk of adverse metabolic outcomes.

Trial registration number

NCT04189796.

SUBMITTER: Lundberg HE

PROVIDER: S-EPMC9813627 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Publications

Effect on bone anabolic markers of daily cheese intake with and without vitamin K<sub>2</sub>: a randomised clinical trial.

Lundberg Helge Einar HE Glasø Morten M Chhura Rahul R Shukla Arjun Andre AA Austlid Torunn T Sarwar Zohaib Z Hovland Kathrine K Iqbal Sapna S Fagertun Hans Erik HE Holo Helge H Larsen Stig Einride SE

BMJ nutrition, prevention & health 20220802 2

<h4>Background</h4>Daily intake of 57 g Jarlsberg cheese has been shown to increase the total serum osteocalcin (tOC). Is this a general cheese effect or specific for Jarlsberg containing vitamin K<sub>2</sub> and 1,4-dihydroxy-2naphtoic acid (DHNA)?<h4>Methods</h4>66 healthy female volunteers (HV) were recruited. By skewed randomisation (3:2), 41 HV were allocated to daily intake of 57 g Jarlsberg (J-group) and 25-50 g Camembert (C-group) in 6 weeks. After 6 weeks the C-group was switched to Ja ...[more]

PMID: 36619332

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Dataset Information

Effect on bone anabolic markers of daily cheese intake with and without vitamin K₂: a randomised clinical trial.

Background

Methods

Results

Conclusion

Trial registration number

Publications

Effect on bone anabolic markers of daily cheese intake with and without vitamin K<sub>2</sub>: a randomised clinical trial.

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Dataset Information

Effect on bone anabolic markers of daily cheese intake with and without vitamin K2: a randomised clinical trial.

Background

Methods

Results

Conclusion

Trial registration number

Publications

Effect on bone anabolic markers of daily cheese intake with and without vitamin K<sub>2</sub>: a randomised clinical trial.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Effect on bone anabolic markers of daily cheese intake with and without vitamin K₂: a randomised clinical trial.