Ontology highlight
ABSTRACT:
SUBMITTER: Zhao R
PROVIDER: S-EPMC9818179 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Zhao Ruzhou R Xu Yixin Y Wang Xiaobo X Zhou Xiang X Liu Yanqi Y Jiang Shuai S Zhang Lin L Yu Zhibin Z
Cells 20221225 1
Rapid adaptation to extreme hypoxia is a challenging problem, and there is no effective scheme to achieve rapid adaptation to extreme hypoxia. In this study, we found that withaferin A (WA) can significantly reduce myocardial damage, maintain cardiac function, and improve survival in rats in extremely hypoxic environments. Mechanistically, WA protects against extreme hypoxia by affecting BCL2-interacting protein 3 (BNIP3)-mediated mitophagy and the peroxisome proliferator-activated receptor γ co ...[more]