Dataset Information

Image-based computer modeling assessment of microwave ablation for treatment of adrenal tumors.

ABSTRACT:

Purpose

To assess the feasibility of delivering microwave ablation for targeted treatment of aldosterone producing adenomas using image-based computational models.

Methods

We curated an anonymized dataset of diagnostic ¹¹C-metomidate PET/CT images of 14 patients with aldosterone producing adenomas (APA). A semi-automated approach was developed to segment the APA, adrenal gland, and adjacent organs within 2 cm of the APA boundary. The segmented volumes were used to implement patient-specific 3D electromagnetic-bioheat transfer models of microwave ablation with a 2.45 GHz directional microwave ablation applicator. Ablation profiles were quantitatively assessed based on the extent of the APA target encompassed by an ablative thermal dose, while limiting thermal damage to the adjacent normal adrenal tissue and sensitive critical structures.

Results

Across the 14 patients, adrenal tumor volumes ranged between 393 mm³ and 2,395 mm³. On average, 70% of the adrenal tumor volumes received an ablative thermal dose of 240CEM43, while limiting thermal damage to non-target structures, and thermally sparing 83.5-96.4% of normal adrenal gland. Average ablation duration was 293 s (range: 60-600 s). Simulations indicated coverage of the APA with an ablative dose was limited when the axis of the ablation applicator was not well aligned with the major axis of the targeted APA.

Conclusions

Image-based computational models demonstrate the potential for delivering microwave ablation to APA targets within the adrenal gland, while limiting thermal damage to surrounding non-target structures.

SUBMITTER: Sebek J

PROVIDER: S-EPMC9820798 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Image-based computer modeling assessment of microwave ablation for treatment of adrenal tumors.

Sebek Jan J Cappiello Grazia G Rahmani George G Zeinali Nooshin N Keating Muireann M Fayemiwo Michael M Harkin Jim J McDaid Liam L Gardiner Bryan B Sheppard Declan D Senanayake Russell R Gurnell Mark M O'Halloran Martin M Dennedy M Conall MC Prakash Punit P

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 20220101 1

<h4>Purpose</h4>To assess the feasibility of delivering microwave ablation for targeted treatment of aldosterone producing adenomas using image-based computational models.<h4>Methods</h4>We curated an anonymized dataset of diagnostic <sup>11</sup>C-metomidate PET/CT images of 14 patients with aldosterone producing adenomas (APA). A semi-automated approach was developed to segment the APA, adrenal gland, and adjacent organs within 2 cm of the APA boundary. The segmented volumes were used to imple ...[more]

PMID: 36137605

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Dataset Information

Image-based computer modeling assessment of microwave ablation for treatment of adrenal tumors.

Purpose

Methods

Results

Conclusions

Publications

Image-based computer modeling assessment of microwave ablation for treatment of adrenal tumors.

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