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Room Temperature Reduction of Titanium Tetrachloride-Activated Nitriles to Primary Amines with Ammonia-Borane.

ABSTRACT: The reduction of a variety of aromatic and aliphatic nitriles, activated by a molar equivalent of titanium tetrachloride, has been achieved at room temperature using ammonia borane as a safe reductant. The corresponding methanamines were isolated in good to excellent yields following a simple acid-base workup.

SUBMITTER: Ramachandran PV

PROVIDER: S-EPMC9822325 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Room Temperature Reduction of Titanium Tetrachloride-Activated Nitriles to Primary Amines with Ammonia-Borane.

Ramachandran P Veeraraghavan PV Alawaed Abdulkhaliq A AA

Molecules (Basel, Switzerland) 20221221 1

The reduction of a variety of aromatic and aliphatic nitriles, activated by a molar equivalent of titanium tetrachloride, has been achieved at room temperature using ammonia borane as a safe reductant. The corresponding methanamines were isolated in good to excellent yields following a simple acid-base workup. ...[more]

PMID: 36615254

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