Dataset Information

Chemical Evaluation of Liquidambar styraciflua L. Fruits Extracts and Their Potential as Anticancer Drugs.

ABSTRACT: Liquidambar styraciflua L. is an aromatic species, popularly used in traditional Chinese medicine to treat diarrhea, dysentery, coughs, and skin sores. The present study was designed to investigate the chemical composition and biological potential of extracts obtained from the fruits of this plant. For the chemical evaluation, it was used mainly liquid and gas chromatography, plus NMR, and colorimetric methods. The aqueous extract (EA) originated two other fractions: an aqueous (P-EA) and an ethanolic (S-EA). The three extracts were composed of proteins, phenolic compounds, and carbohydrates in different proportions. The analyses showed that the polysaccharide extract (P-EA) contained pectic polysaccharides, such as acetylated and methyl esterified homogalacturonans together with arabinogalactan, while the fraction S-EA presented phenolic acids and terpenes such as gallic acid, protocathecuic acid, liquidambaric acid, combretastatin, and atractyloside A. EA, P-EA, and S-EA showed antioxidant activity, with IC₅₀ values of 4.64 µg/mL, 16.45 µg/mL, and 3.67 µg/mL, respectively. The cytotoxicity followed the sequence S-EA > EA > P-EA, demonstrating that the toxic compounds were separated from the non-toxic ones by ethanol precipitation. While the fraction S-EA is very toxic to any cell line, the fraction P-EA is a promising candidate for studies against cancer due to its high toxicity to tumoral cells and low toxicity to normal cells.

SUBMITTER: Pozzobon RG

PROVIDER: S-EPMC9822488 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Chemical Evaluation of <i>Liquidambar styraciflua</i> L. Fruits Extracts and Their Potential as Anticancer Drugs.

Pozzobon Rafaela G RG Rutckeviski Renata R Carlotto Juliane J Schneider Vanessa S VS Cordeiro Lucimara M C LMC Mancarz Graziele Francine Franco GFF Souza Lauro M de LM Mello Rosiane Guetter RG Smiderle Fhernanda Ribeiro FR

Molecules (Basel, Switzerland) 20230101 1

Liquidambar styraciflua L. is an aromatic species, popularly used in traditional Chinese medicine to treat diarrhea, dysentery, coughs, and skin sores. The present study was designed to investigate the chemical composition and biological potential of extracts obtained from the fruits of this plant. For the chemical evaluation, it was used mainly liquid and gas chromatography, plus NMR, and colorimetric methods. The aqueous extract (EA) originated two other fractions: an aqueous (P-EA) and an eth ...[more]

PMID: 36615553

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Dataset Information

Chemical Evaluation of Liquidambar styraciflua L. Fruits Extracts and Their Potential as Anticancer Drugs.

Publications

Chemical Evaluation of <i>Liquidambar styraciflua</i> L. Fruits Extracts and Their Potential as Anticancer Drugs.

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