Dataset Information

Symbolic kinetic models in python (SKiMpy): intuitive modeling of large-scale biological kinetic models.

ABSTRACT:

Motivation

Large-scale kinetic models are an invaluable tool to understand the dynamic and adaptive responses of biological systems. The development and application of these models have been limited by the availability of computational tools to build and analyze large-scale models efficiently. The toolbox presented here provides the means to implement, parameterize and analyze large-scale kinetic models intuitively and efficiently.

Results

We present a Python package (SKiMpy) bridging this gap by implementing an efficient kinetic modeling toolbox for the semiautomatic generation and analysis of large-scale kinetic models for various biological domains such as signaling, gene expression and metabolism. Furthermore, we demonstrate how this toolbox is used to parameterize kinetic models around a steady-state reference efficiently. Finally, we show how SKiMpy can implement multispecies bioreactor simulations to assess biotechnological processes.

Availability and implementation

The software is available as a Python 3 package on GitHub: https://github.com/EPFL-LCSB/SKiMpy, along with adequate documentation.

Supplementary information

Supplementary data are available at Bioinformatics online.

SUBMITTER: Weilandt DR

PROVIDER: S-EPMC9825757 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Publications

Symbolic kinetic models in python (SKiMpy): intuitive modeling of large-scale biological kinetic models.

Weilandt Daniel R DR Salvy Pierre P Masid Maria M Fengos Georgios G Denhardt-Erikson Robin R Hosseini Zhaleh Z Hatzimanikatis Vassily V

Bioinformatics (Oxford, England) 20230101 1

<h4>Motivation</h4>Large-scale kinetic models are an invaluable tool to understand the dynamic and adaptive responses of biological systems. The development and application of these models have been limited by the availability of computational tools to build and analyze large-scale models efficiently. The toolbox presented here provides the means to implement, parameterize and analyze large-scale kinetic models intuitively and efficiently.<h4>Results</h4>We present a Python package (SKiMpy) brid ...[more]

PMID: 36495209

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Dataset Information

Symbolic kinetic models in python (SKiMpy): intuitive modeling of large-scale biological kinetic models.

Motivation

Results

Availability and implementation

Supplementary information

Publications

Symbolic kinetic models in python (SKiMpy): intuitive modeling of large-scale biological kinetic models.

Similar Datasets

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