Kir4.2 mediates proximal potassium effects on glutaminase activity and kidney injury.
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ABSTRACT:
SUBMITTER: Terker AS
PROVIDER: S-EPMC9827473 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
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Kir4.2 mediates proximal potassium effects on glutaminase activity and kidney injury.
Terker Andrew S AS Zhang Yahua Y Arroyo Juan Pablo JP Cao Shirong S Wang Suwan S Fan Xiaofeng X Denton Jerod S JS Zhang Ming-Zhi MZ Harris Raymond C RC
Cell reports 20221201 12
Inadequate potassium (K<sup>+</sup>) consumption correlates with increased mortality and poor cardiovascular outcomes. Potassium effects on blood pressure have been described previously; however, whether or not low K<sup>+</sup> independently affects kidney disease progression remains unclear. Here, we demonstrate that dietary K<sup>+</sup> deficiency causes direct kidney injury. Effects depend on reduced blood K<sup>+</sup> and are kidney specific. In response to reduced K<sup>+</sup>, the chan ...[more]
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