Dataset Information

Glucose variability increases during minimally invasive procedures in very preterm infants.

ABSTRACT: The objective of this study is to assess the effect of neonatal procedures on glucose variability in very preterm infants. Preterm infants (≤ 32 weeks gestation and/or birthweight ≤ 1500 g) were started on continuous glucose monitoring (CGM) on day 2 of birth and monitored for 5 days. Minimally invasive (heel stick, venipunctures) and non-invasive (nappy change, parental presence) procedures were recorded. CGM data were analyzed 30 min before and after each procedure. The primary outcome was the coefficient of glucose variation (CV = SD/mean) before and after the procedure; SD and median glucose were also evaluated. We analyzed 496 procedures in 22 neonates (GA 30.5 weeks [29-31]; birthweight 1300 g [950-1476]). Median glucose did not change before and after each procedure, while CV and SD increased after heel prick (p = 0.017 and 0.030), venipuncture (p = 0.010 and 0.030), and nappy change (p < 0.001 and < 0.001), in the absence of a difference during parental presence.

Conclusions

Non-invasive and minimally invasive procedures increase glucose variability in the absence of changes of mean glucose.

What is known

• Minimally invasive procedures - including nappy change - may increase neonatal stress in preterm infants.

What is new

• Continuous glucose monitoring provides a quantitative measure of neonatal stress during neonatal care procedures demonstrating an increase of glucose variability.

SUBMITTER: Galderisi A

PROVIDER: S-EPMC9829573 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Publications

Glucose variability increases during minimally invasive procedures in very preterm infants.

Galderisi Alfonso A Res Giulia G Guiducci Silvia S Savio Federica F Brigadoi Sabrina S Forlani Laura L Mastrandrea Biancamaria B Moschino Laura L Lolli Elisabetta E Priante Elena E Trevisanuto Daniele D Baraldi Eugenio E

European journal of pediatrics 20221006 1

The objective of this study is to assess the effect of neonatal procedures on glucose variability in very preterm infants. Preterm infants (≤ 32 weeks gestation and/or birthweight ≤ 1500 g) were started on continuous glucose monitoring (CGM) on day 2 of birth and monitored for 5 days. Minimally invasive (heel stick, venipunctures) and non-invasive (nappy change, parental presence) procedures were recorded. CGM data were analyzed 30 min before and after each procedure. The primary outcome was the ...[more]

PMID: 36201017

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Dataset Information

Glucose variability increases during minimally invasive procedures in very preterm infants.

Conclusions

What is known

What is new

Publications

Glucose variability increases during minimally invasive procedures in very preterm infants.

Similar Datasets

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