Dataset Information

Statin contribution to middle cerebral artery blood flow velocity in older adults at risk for dementia.

ABSTRACT:

Purpose

It is plausible that statins could improve cerebral blood flow through pleiotropic mechanisms. The purpose of this investigation was to assess the contribution of statins to cerebrovascular variables in older adults with dyslipidemia and familial history of dementia. Furthermore, we explored the interaction between statin use and sex due to prevalent bias in statin trials.

Methods

Middle cerebral artery blood flow velocity (MCAv) was measured using transcranial Doppler ultrasound. Continuous supine rest recordings lasted 8 min. Participants included in analyses were statin (n = 100) or non-statin users (n = 112).

Results

MCAv and cerebrovascular conductance were significantly higher in statin users (p = 0.047; p = 0.04), and pulsatility index (PI) was significantly lower in statin users (p < 0.01). An interaction effect between statin use and sex was present for PI (p = 0.02); female statin users had significantly lower cerebrovascular resistance than the other three groups.

Conclusion

In this cross-sectional analysis, statin use was positively associated with cerebrovascular variables in older adults at risk for dementia. Female statin users had significantly higher resting MCAv and cerebrovascular conductance than female non-statin users. The greatest contribution of statin use was the association with reduced cerebrovascular resistance. Given that cerebrovascular dysregulation is one of the earliest changes in Alzheimer's disease and related dementia pathology, targeting the cerebrovasculature with statins may be a promising prevention strategy.

SUBMITTER: Aaron SE

PROVIDER: S-EPMC9830632 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Publications

Statin contribution to middle cerebral artery blood flow velocity in older adults at risk for dementia.

Aaron Stacey E SE Tomoto Tsubasa T Zhang Rong R Thyfault John P JP Vidoni Eric D ED Montgomery Robert N RN Burns Jeffrey M JM Billinger Sandra A SA

European journal of applied physiology 20220812 11

<h4>Purpose</h4>It is plausible that statins could improve cerebral blood flow through pleiotropic mechanisms. The purpose of this investigation was to assess the contribution of statins to cerebrovascular variables in older adults with dyslipidemia and familial history of dementia. Furthermore, we explored the interaction between statin use and sex due to prevalent bias in statin trials.<h4>Methods</h4>Middle cerebral artery blood flow velocity (MCAv) was measured using transcranial Doppler ult ...[more]

PMID: 35960268

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Dataset Information

Statin contribution to middle cerebral artery blood flow velocity in older adults at risk for dementia.

Purpose

Methods

Results

Conclusion

Publications

Statin contribution to middle cerebral artery blood flow velocity in older adults at risk for dementia.

Similar Datasets

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