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Safety and Tolerability of Nicotinamide Riboside in Heart Failure With Reduced Ejection Fraction.


ABSTRACT: The mitochondrial dysfunction characteristic of heart failure (HF) is associated with changes in intracellular nicotinamide adenine dinucleotide (NAD+) and NADH levels. Raising NAD+ levels with the NAD+ precursor, nicotinamide riboside (NR), may represent a novel HF treatment. In this 30-participant trial of patients with clinically stable HF with reduced ejection fraction, NR, at a dose of 1,000 mg twice daily, appeared to be safe and well tolerated, and approximately doubled whole blood NAD+ levels. Intraindividual NAD+ increases in response to NR correlated with increases in peripheral blood mononuclear cell basal (R 2 = 0.413, P = 0.003) and maximal (R 2 = 0.434, P = 0.002) respiration, and with decreased NLRP3 expression (R 2 = 0.330, P = 0.020). (Nicotinamide Riboside in Systolic Heart Failure; NCT03423342).

SUBMITTER: Wang DD 

PROVIDER: S-EPMC9831861 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Safety and Tolerability of Nicotinamide Riboside in Heart Failure With Reduced Ejection Fraction.

Wang Dennis D DD   Airhart Sophia E SE   Zhou Bo B   Shireman Laura M LM   Jiang Siyi S   Melendez Rodriguez Carolina C   Kirkpatrick James N JN   Shen Danny D DD   Tian Rong R   O'Brien Kevin D KD  

JACC. Basic to translational science 20220914 12


The mitochondrial dysfunction characteristic of heart failure (HF) is associated with changes in intracellular nicotinamide adenine dinucleotide (NAD<sup>+</sup>) and NADH levels. Raising NAD<sup>+</sup> levels with the NAD<sup>+</sup> precursor, nicotinamide riboside (NR), may represent a novel HF treatment. In this 30-participant trial of patients with clinically stable HF with reduced ejection fraction, NR, at a dose of 1,000 mg twice daily, appeared to be safe and well tolerated, and approxi  ...[more]

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