Ontology highlight
ABSTRACT:
SUBMITTER: Wang DD
PROVIDER: S-EPMC9831861 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Wang Dennis D DD Airhart Sophia E SE Zhou Bo B Shireman Laura M LM Jiang Siyi S Melendez Rodriguez Carolina C Kirkpatrick James N JN Shen Danny D DD Tian Rong R O'Brien Kevin D KD
JACC. Basic to translational science 20220914 12
The mitochondrial dysfunction characteristic of heart failure (HF) is associated with changes in intracellular nicotinamide adenine dinucleotide (NAD<sup>+</sup>) and NADH levels. Raising NAD<sup>+</sup> levels with the NAD<sup>+</sup> precursor, nicotinamide riboside (NR), may represent a novel HF treatment. In this 30-participant trial of patients with clinically stable HF with reduced ejection fraction, NR, at a dose of 1,000 mg twice daily, appeared to be safe and well tolerated, and approxi ...[more]