Dataset Information

Unusual Trigger for Contractile Movements of Optic Disc in Peripapillary Staphyloma.

ABSTRACT:

Purpose

To report a case of contractile movements of the optic disc in peripapillary staphyloma.

Methods

A 65-year-old female received a comprehensive ophthalmic examination, multimodal imaging, and computed tomography.

Results

The patient was diagnosed with peripapillary staphyloma in her right eye. Best-corrected visual acuity in her right and left eye was 20/32 and 20/40, respectively, with moderate cataracts in both eyes. Multimodal imaging revealed contractile movements of the optic disc in the right eye that were initiated by the circular rotation of the eye but by none of the triggers previously described in the literature. The patient reported no changes in her vision during contractile movements. Optical coherence tomography revealed a muscle-like structure in the optic disc during the peak of the contraction. Computed tomography did not reveal any abnormality of the optic nerve or the extraocular muscles of the right eye.

Conclusion

Contractile movements in peripapillary staphyloma may be initiated by previously unknown triggers. The pattern of the contractile movements and optical coherence tomography findings support the muscular nature of these movements.

SUBMITTER: Nevin NV

PROVIDER: S-EPMC9832455 | biostudies-literature | 2022 Jul-Sep

REPOSITORIES: biostudies-literature

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Publications

Unusual Trigger for Contractile Movements of Optic Disc in Peripapillary Staphyloma.

Nevin Nikolai V NV Kulikov Alexei N AN Danilenko Ekaterina V EV Maltsev Dmitrii S DS

Journal of current ophthalmology 20220701 3

<h4>Purpose</h4>To report a case of contractile movements of the optic disc in peripapillary staphyloma.<h4>Methods</h4>A 65-year-old female received a comprehensive ophthalmic examination, multimodal imaging, and computed tomography.<h4>Results</h4>The patient was diagnosed with peripapillary staphyloma in her right eye. Best-corrected visual acuity in her right and left eye was 20/32 and 20/40, respectively, with moderate cataracts in both eyes. Multimodal imaging revealed contractile movement ...[more]

PMID: 36644460

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Project description:Background: Limited information is known about the topographic effect of optic disc drusen (ODD) on peripapillary retinal nerve fibers and microvasculature. Objective: This study aims to understand the structural and functional impact of ODD in different quadrants of the optic disc. Methods: We performed a retrospective case-control study of 22 ODD patients (34 eyes) and 26 controls (33 eyes) to compare optical coherence tomography (OCT) retinal nerve fiber layer (RNFL), OCT angiography (OCTA), and corresponding static perimetry mean deviation (MD) calculated using the modified Garway-Heath map in different quadrants of the optic disc. OCTA was analyzed using custom MATLAB script to measure six parameters in a peripapillary annulus with large vessel removal: vessel area density (VAD), vessel skeleton density (VSD), vessel perimeter index (VPI), vessel complexity index (VCI), flux, and vessel diameter index (VDI). Results: Quadrant analysis revealed that OCTA VAD and VCI were significantly decreased in superior, nasal, and inferior but not temporal quadrant. RNFL, VSD, and VPI were significantly impacted only in the superior and nasal quadrants. Corresponding visual field MDs in all ODD eyes were not different in the four quadrants, although eyes with MD equal or worse than -5 dB (32%) had worst visual field corresponding to the superior quadrant of the optic disc (inferior arcuate visual field). Structure-structure comparison of OCT and OCTA showed high correlation of RNFL with multiple OCTA measurements in the superior, nasal, and inferior quadrants but not temporal quadrant. Structure-function analysis revealed significant correlation of VAD and VCI and visual field MD in every quadrant, but RNFL was only significantly correlated in the superior and inferior quadrants. Conclusions: Peripapillary VAD and VCI are decreased in more quadrants than RNFL, supporting the clinical utility of performing OCTA in addition to OCT. Consistent with the most common locations of ODD, five OCT/OCTA measurements (VAD, VCI, RNFL, VSD, VPI) are decreased in the superior and nasal quadrants. OCT/OCTA measurements were significantly impacted in contrast to the relatively mild effect on corresponding visual field MD, consistent with the idea that a decrease in objective structural and vascular measurements occurs without parallel change in subjective visual function in ODD.

Project description:PurposeTo demonstrate papillary imaging of eyes with optic disc pits (ODP) or optic disc pit associated maculopathy (ODP-M) with ultrahigh-speed swept-source optical coherence tomography (SS-OCT) at 1.68 million A-scans/s. To generate 3D-renderings of the papillary area with 3D volume-reconstructions of the ODP and highly resolved en face images from a single densely-sampled megahertz-OCT (MHz-OCT) dataset for investigation of ODP-characteristics.MethodsA 1.68 MHz-prototype SS-MHz-OCT system at 1050 nm based on a Fourier-domain mode-locked laser was employed to acquire high-definition, 3D datasets with a dense sampling of 1600 × 1600 A-scans over a 45° field of view. Six eyes with ODPs, and two further eyes with glaucomatous alteration or without ocular pathology are presented. 3D-rendering of the deep papillary structures, virtual 3D-reconstructions of the ODPs and depth resolved isotropic en face images were generated using semiautomatic segmentation.Results3D-rendering and en face imaging of the optic disc, ODPs and ODP associated pathologies showed a broad spectrum regarding ODP characteristics. Between individuals the shape of the ODP and the appending pathologies varied considerably. MHz-OCT en face imaging generates distinct top-view images of ODPs and ODP-M. MHz-OCT generates high resolution images of retinal pathologies associated with ODP-M and allows visualizing ODPs with depths of up to 2.7 mm.ConclusionsDifferent patterns of ODPs can be visualized in patients for the first time using 3D-reconstructions and co-registered high-definition en face images extracted from a single densely sampled 1050 nm megahertz-OCT (MHz-OCT) dataset. As the immediate vicinity to the SAS and the site of intrapapillary proliferation is located at the bottom of the ODP it is crucial to image the complete structure and the whole depth of ODPs. Especially in very deep pits, where non-swept-source OCT fails to reach the bottom, conventional swept-source devices and the MHz-OCT alike are feasible and beneficial methods to examine deep details of optic disc pathologies, while the MHz-OCT bears the advantage of an essentially swifter imaging process.

Dataset Information

Unusual Trigger for Contractile Movements of Optic Disc in Peripapillary Staphyloma.

Purpose

Methods

Results

Conclusion

Publications

Unusual Trigger for Contractile Movements of Optic Disc in Peripapillary Staphyloma.

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