Cholesterol efflux promoting function of high-density lipoproteins in calcific aortic valve stenosis

ABSTRACT:

Background and aims

Cholesterol efflux capacity is a functional property of high-density lipoproteins (HDL) reflecting the efficiency of the atheroprotective reverse cholesterol transport process in humans. Its relationship with calcific aortic valve stenosis (CAVS) has not been fully assessed yet.

Methods

We evaluated HDL-CEC in a patient population with varying degrees of aortic valvular calcific disease, assessed using echocardiography and cardiac computed tomography. Measurement of biomarkers that reflect osteogenic and tissue remodeling, along with dietary and gut microbiota-derived metabolites were performed.

Results

Patients with moderate-severe CAVS had significantly lower HDL-CEC compared to both control and aortic sclerosis subjects (mean: 6.09%, 7.32% and 7.26%, respectively). HDL-CEC displayed negative correlations with peak aortic jet velocity and aortic valve calcium score, indexes of CAVS severity (ρ = -0.298, p = 0.002 and ρ = -0.358, p = 0.005, respectively). In multivariable regression model, HDL-CEC had independent association with aortic valve calcium score (B: -0.053, SE: 0.014, p < 0.001), GFR (B: -0.034, SE: 0.012, p = 0.007), as well as with levels of total cholesterol (B: 0.018, SE: 0.005, p = 0.002).

Conclusion

These results indicate an impairment of HDL-CEC in moderate-severe CAVS and may contribute to identify potential novel targets for CAVS management. Graphical abstract HDL cholesterol efflux capacity is impaired with a pattern depending on severity of calcific aortic valve stenosis and is independently associated with aortic valve calcium score, GFR and total cholesterol.Image 1 Highlights • HDL-CEC is impaired with a pattern depending on severity of CAVS.• HDL-CEC is correlated with diagnostic and prognostic imaging parameters in CAVS.• HDL-CEC is independently associated with aortic valve calcium score.

SUBMITTER: Kocyigit D 

PROVIDER: S-EPMC9833266 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature