Dataset Information

Usefulness of endocytoscopy in evaluating transbronchial biopsy specimens.

ABSTRACT:

Background

Endocytoscopy (ECS) provides a magnification of approximately 450× for real-time observation of lesion nuclei. Using ECS, we aimed to evaluate whether sufficient samples for diagnosis can be obtained during bronchoscopy. We also investigated whether ECS can enable two-class diagnosis of malignant or non-malignant transbronchial biopsy specimens in real-time during bronchoscopy.

Methods

This was a single-facility, prospective, observational, ex vivo study. Forty cases with localized peripheral pulmonary lesions underwent transbronchial biopsy with endobronchial ultrasonography using a guide sheath. Each biopsy specimen was immediately observed and evaluated endocytoscopically after the collection by the bronchoscopic procedure.

Results

Thirty-seven cases were enrolled. The diagnostic accuracy achieved by ECS was 91.9% (34/37). The agreement rate between the endocytoscopic evaluation and pathological diagnosis of each specimen (170 specimens) was 65.3% (111/170). The median time required for endocytoscopic evaluation per specimen was 70 s. When we judged a specimen to be malignant a second time on ECS evaluations of five specimens in one case, pathologically malignant specimens were collected in 26 of 27 cases (96.3%).

Conclusions

ECS with methylene blue staining may aid in the two-class diagnosis of malignant or non-malignant transbronchial biopsy specimens during bronchoscopy. This may reduce the number of tissue biopsies.

SUBMITTER: Okuno T

PROVIDER: S-EPMC9834692 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Publications

Usefulness of endocytoscopy in evaluating transbronchial biopsy specimens.

Okuno Takae T Kurimoto Noriaki N Tanino Akari A Hamaguchi Megumi M Hotta Takamasa T Tanino Ryosuke R Kobayashi Misato M Shiratsuki Yohei Y Hamaguchi Shunichi S Isobe Takeshi T Tsubata Yukari Y

Thoracic cancer 20221122 2

<h4>Background</h4>Endocytoscopy (ECS) provides a magnification of approximately 450× for real-time observation of lesion nuclei. Using ECS, we aimed to evaluate whether sufficient samples for diagnosis can be obtained during bronchoscopy. We also investigated whether ECS can enable two-class diagnosis of malignant or non-malignant transbronchial biopsy specimens in real-time during bronchoscopy.<h4>Methods</h4>This was a single-facility, prospective, observational, ex vivo study. Forty cases wi ...[more]

PMID: 36415054

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Dataset Information

Usefulness of endocytoscopy in evaluating transbronchial biopsy specimens.

Background

Methods

Results

Conclusions

Publications

Usefulness of endocytoscopy in evaluating transbronchial biopsy specimens.

Similar Datasets

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