Multimodal optical imaging with real-time projection of cancer risk and biopsy guidance maps for early oral cancer diagnosis and treatment.
Ontology highlight
ABSTRACT: Significance
Despite recent advances in multimodal optical imaging, oral imaging systems often do not provide real-time actionable guidance to the clinician who is making biopsy and treatment decisions.Aim
We demonstrate a low-cost, portable active biopsy guidance system (ABGS) that uses multimodal optical imaging with deep learning to directly project cancer risk and biopsy guidance maps onto oral mucosa in real time.Approach
Cancer risk maps are generated based on widefield autofluorescence images and projected onto the at-risk tissue using a digital light projector. Microendoscopy images are obtained from at-risk areas, and multimodal image data are used to calculate a biopsy guidance map, which is projected onto tissue.Results
Representative patient examples highlight clinically actionable visualizations provided in real time during an imaging procedure. Results show multimodal imaging with cancer risk and biopsy guidance map projection offers a versatile, quantitative, and precise tool to guide biopsy site selection and improve early detection of oral cancers.Conclusions
The ABGS provides direct visible guidance to identify early lesions and locate appropriate sites to biopsy within those lesions. This represents an opportunity to translate multimodal imaging into real-time clinically actionable visualizations to help improve patient outcomes.
SUBMITTER: Coole JB
PROVIDER: S-EPMC9838568 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Publications
Multimodal optical imaging with real-time projection of cancer risk and biopsy guidance maps for early oral cancer diagnosis and treatment.
Coole Jackson B JB Brenes David D Mitbander Ruchika R Vohra Imran I Hou Huayu H Kortum Alex A Tang Yubo Y Maker Yajur Y Schwarz Richard A RA Carns Jennifer J Badaoui Hawraa H Williams Michelle M Vigneswaran Nadarajah N Gillenwater Ann A Richards-Kortum Rebecca R
Journal of biomedical optics 20230113 1
<h4>Significance</h4>Despite recent advances in multimodal optical imaging, oral imaging systems often do not provide real-time actionable guidance to the clinician who is making biopsy and treatment decisions.<h4>Aim</h4>We demonstrate a low-cost, portable active biopsy guidance system (ABGS) that uses multimodal optical imaging with deep learning to directly project cancer risk and biopsy guidance maps onto oral mucosa in real time.<h4>Approach</h4>Cancer risk maps are generated based on widef ...[more]
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