Ontology highlight
ABSTRACT:
SUBMITTER: Lian X
PROVIDER: S-EPMC9839361 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Lian Xiaodong X Seiger Kyra W KW Parsons Elizabeth M EM Gao Ce C Sun Weiwei W Gladkov Gregory T GT Roseto Isabelle C IC Einkauf Kevin B KB Osborn Matthew R MR Chevalier Joshua M JM Jiang Chenyang C Blackmer Jane J Carrington Mary M Rosenberg Eric S ES Lederman Michael M MM McMahon Deborah K DK Bosch Ronald J RJ Jacobson Jeffrey M JM Gandhi Rajesh T RT Peluso Michael J MJ Chun Tae-Wook TW Deeks Steven G SG Yu Xu G XG Lichterfeld Mathias M
Cell host & microbe 20230102 1
HIV-1 establishes a life-long reservoir of virally infected cells which cannot be eliminated by antiretroviral therapy (ART). Here, we demonstrate a markedly altered viral reservoir profile of long-term ART-treated individuals, characterized by large clones of intact proviruses preferentially integrated in heterochromatin locations, most prominently in centromeric satellite/micro-satellite DNA. Longitudinal evaluations suggested that this specific reservoir configuration results from selection p ...[more]