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The identification of metabolites from gut microbiota in NAFLD via network pharmacology.

ABSTRACT: The metabolites of gut microbiota show favorable therapeutic effects on nonalcoholic fatty liver disease (NAFLD), but the active metabolites and mechanisms against NAFLD have not been documented. The aim of the study was to investigate the active metabolites and mechanisms of gut microbiota against NAFLD by network pharmacology. We obtained a total of 208 metabolites from the gutMgene database and retrieved 1256 targets from similarity ensemble approach (SEA) and 947 targets from the SwissTargetPrediction (STP) database. In the SEA and STP databases, we identified 668 overlapping targets and obtained 237 targets for NAFLD. Thirty-eight targets were identified out of those 237 and 223 targets retrieved from the gutMgene database, and were considered the final NAFLD targets of metabolites from the microbiome. The results of molecular docking tests suggest that, of the 38 targets, mitogen-activated protein kinase 8-compound K and glycogen synthase kinase-3 beta-myricetin complexes might inhibit the Wnt signaling pathway. The microbiota-signaling pathways-targets-metabolites network analysis reveals that Firmicutes, Fusobacteria, the Toll-like receptor signaling pathway, mitogen-activated protein kinase 1, and phenylacetylglutamine are notable components of NAFLD and therefore to understanding its processes and possible therapeutic approaches. The key components and potential mechanisms of metabolites from gut microbiota against NAFLD were explored utilizing network pharmacology analyses. This study provides scientific evidence to support the therapeutic efficacy of metabolites for NAFLD and suggests holistic insights on which to base further research.

SUBMITTER: Oh KK

PROVIDER: S-EPMC9839744 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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The identification of metabolites from gut microbiota in NAFLD via network pharmacology.

Oh Ki-Kwang KK Gupta Haripriya H Min Byeong Hyun BH Ganesan Raja R Sharma Satya Priya SP Won Sung Min SM Jeong Jin Ju JJ Lee Su Been SB Cha Min Gi MG Kwon Goo Hyun GH Jeong Min Kyo MK Hyun Ji Ye JY Eom Jung A JA Park Hee Jin HJ Yoon Sang Jun SJ Choi Mi Ran MR Kim Dong Joon DJ Suk Ki Tae KT

Scientific reports 20230113 1

The metabolites of gut microbiota show favorable therapeutic effects on nonalcoholic fatty liver disease (NAFLD), but the active metabolites and mechanisms against NAFLD have not been documented. The aim of the study was to investigate the active metabolites and mechanisms of gut microbiota against NAFLD by network pharmacology. We obtained a total of 208 metabolites from the gutMgene database and retrieved 1256 targets from similarity ensemble approach (SEA) and 947 targets from the SwissTarget ...[more]

PMID: 36639568

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The identification of metabolites from gut microbiota in NAFLD via network pharmacology.

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The identification of metabolites from gut microbiota in NAFLD via network pharmacology.

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