Ontology highlight
ABSTRACT:
SUBMITTER: Ni QZ
PROVIDER: S-EPMC9839844 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Ni Qian-Zhi QZ Zhu Bing B Ji Yan Y Zheng Qian-Wen QW Liang Xin X Ma Ning N Jiang Hao H Zhang Feng-Kun FK Shang Yu-Rong YR Wang Yi-Kang YK Xu Sheng S Zhang Er-Bin EB Yuan Yan-Mei YM Chen Tian-Wei TW Yin Fen-Fen FF Cao Hui-Jun HJ Huang Jing-Yi JY Xia Ji J Ding Xu-Fen XF Qiu Xiao-Song XS Ding Kai K Song Chao C Zhou Wen-Tao WT Wu Meng M Wang Kang K Lui Rui R Lin Qiu Q Chen Wei W Li Zhi-Gang ZG Cheng Shu-Qun SQ Wang Xiao-Fan XF Xie Dong D Li Jing-Jing JJ
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20221201 2
The guanine nucleotide exchange factor (GEF) SOS1 catalyzes the exchange of GDP for GTP on RAS. However, regulation of the GEF activity remains elusive. Here, the authors report that PPDPF functions as an important regulator of SOS1. The expression of PPDPF is significantly increased in pancreatic ductal adenocarcinoma (PDAC), associated with poor prognosis and recurrence of PDAC patients. Overexpression of PPDPF promotes PDAC cell growth in vitro and in vivo, while PPDPF knockout exerts opposit ...[more]