Dataset Information

Radiologic Subtypes and Treatment Outcome of Unclassifiable Type Mycobacterium avium Complex Pulmonary Disease.

ABSTRACT:

Background

Although the "unclassifiable type" is categorized as one of the radiologic classifications in Mycobacterium avium complex (MAC) pulmonary disease (PD), there have been few studies of this type thus far. We aimed to investigate the radiologic subtypes and treatment outcome of unclassifiable type MAC-PD.

Methods

Ninety-six patients with unclassifiable type MAC-PD who initiated a macrolide-containing regimen from 2001 to 2020 were identified at a tertiary referral center in South Korea. Among these 96 patients, 1-year culture conversion rate was analyzed for 48 patients who received standard treatment (three-drug oral-antibiotic combination with or without an injectable agent) for ≥ 1 year.

Results

The mean age of the 96 patients was 65.4 ± 10.8 years, and 72.9% of them were male. These patients were classified into four major radiologic subtypes; the most common subtype was the focal cavity subtype (n = 31, 32.3%), followed by the focal mass or nodule (n = 23, 24.0%), consolidation upon emphysema (n = 21, 21.9%), and bronchiolitis (n = 21, 21.9%) subtypes. For the 48 patients who received standard treatment for ≥ 1 year, the overall rate of culture conversion at 1-year was 93.8%. All patients in the focal cavity subtype and focal mass or nodule subtype categories achieved 1-year culture conversion. Additionally, 1-year culture conversion rate was 92.9% in consolidation upon emphysema subtype and 75.0% in bronchiolitis subtype.

Conclusion

Unclassifiable type MAC-PD can be radiologically further categorized into four major radiologic subtypes. The treatment outcome of all of these subtypes seems to be favorable.

SUBMITTER: Lee JH

PROVIDER: S-EPMC9842488 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Publications

Radiologic Subtypes and Treatment Outcome of Unclassifiable Type <i>Mycobacterium avium</i> Complex Pulmonary Disease.

Lee Jang Ho JH Park Yea Eun YE Chong Yong Pil YP Lee Hyun Joo HJ Shim Tae Sun TS Jo Kyung-Wook KW

Journal of Korean medical science 20230116 3

<h4>Background</h4>Although the "unclassifiable type" is categorized as one of the radiologic classifications in <i>Mycobacterium avium</i> complex (MAC) pulmonary disease (PD), there have been few studies of this type thus far. We aimed to investigate the radiologic subtypes and treatment outcome of unclassifiable type MAC-PD.<h4>Methods</h4>Ninety-six patients with unclassifiable type MAC-PD who initiated a macrolide-containing regimen from 2001 to 2020 were identified at a tertiary referral c ...[more]

PMID: 36647217

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