Modifications to a Biphenolic Antibacterial Compound: Activity against ESKAPE Pathogens.
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ABSTRACT:
SUBMITTER: Roenfanz HF
PROVIDER: S-EPMC9851968 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
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Modifications to a Biphenolic Antibacterial Compound: Activity against ESKAPE Pathogens.
Roenfanz Hanna F HF Ochoa Cristian R CR Kozlowski Marisa C MC
ChemMedChem 20221203 2
Forty-four analogs of honokiol, a compound with known antibacterial activity, especially with respect to oral bacteria, were synthesized to explore the structure-activity relationships against the ESKAPE pathogens. Compounds with high therapeutic indices (hemolysis<sub>20</sub> /MIC) were identified. In particular, ester-linked compounds that would be less than environmentally durable than biaryl ether antibacterials such as the broadly used triclosan were found to be active. MRSA mutants could ...[more]
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