Ontology highlight
ABSTRACT:
SUBMITTER: Nasr ISA
PROVIDER: S-EPMC9855371 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Nasr Ibrahim S Al ISA Koko Waleed S WS Khan Tariq A TA Schobert Rainer R Biersack Bernhard B
Biomedicines 20230114 1
A series of fourteen pyrimido[1,2-<i>a</i>]benzimidazole compounds was prepared by straightforward heterocyclic chemistry and oxidation methods. The new pyrimidobenzimidazole derivative <b>2a</b> with a 3-fluorophenyl substituent was identified as a new antiparasitic compound showing excellent activities against <i>Leishmania major</i> parasites. <b>2a</b> was highly active against <i>L. major</i> promastigotes and amastigotes with EC<sub>50</sub> values in the nanomolar concentration range. Com ...[more]