Identification and analysis of Staphylococcus aureus components expressed by a model system of growth in serum.
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ABSTRACT:
SUBMITTER: Wiltshire MD
PROVIDER: S-EPMC98621 | biostudies-literature | 2001 Aug
REPOSITORIES: biostudies-literature
Publications
Identification and analysis of Staphylococcus aureus components expressed by a model system of growth in serum.
Wiltshire M D MD Foster S J SJ
Infection and immunity 20010801 8
A model system mimicking Staphylococcus aureus bacteremia was developed by growth in serum under microaerobic conditions. Eight genes induced by growth in serum were identified, including an antimicrobial peptide biosynthesis locus, amino acid biosynthetic loci, and genes encoding putative surface proteins. Nine independent insertions were found in the major lysine biosynthesis operon, which encodes eight genes, is repressed by lysine in vitro, and is expressed in vivo. ...[more]
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