Cannabinoid Biosynthesis Using Noncanonical Cannabinoid Synthases.
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ABSTRACT:
SUBMITTER: Go MK
PROVIDER: S-EPMC9862763 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Publications
Cannabinoid Biosynthesis Using Noncanonical Cannabinoid Synthases.
Go Maybelle Kho MK Zhu Tingting T Lim Kevin Jie Han KJH Hartono Yossa Dwi YD Xue Bo B Fan Hao H Yew Wen Shan WS
International journal of molecular sciences 20230109 2
We report enzymes from the berberine bridge enzyme (BBE) superfamily that catalyze the oxidative cyclization of the monoterpene moiety in cannabigerolic acid (CBGA) to form cannabielsoin (CBE). The enzymes are from a variety of organisms and are previously uncharacterized. Out of 232 homologues chosen from the enzyme superfamily, four orthologues were shown to accept CBGA as a substrate and catalyze the biosynthesis of CBE. The four enzymes discovered in this study were recombinantly expressed a ...[more]
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