Ontology highlight
ABSTRACT:
SUBMITTER: El Abbouchi A
PROVIDER: S-EPMC9865193 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
El Abbouchi Abdelmoula A El Brahmi Nabil N Hiebel Marie-Aude MA Ghammaz Hamza H El Fahime Elmostafa E Bignon Jérôme J Guillaumet Gérald G Suzenet Franck F El Kazzouli Saïd S
Molecules (Basel, Switzerland) 20230116 2
The present study aims to report the design, synthesis, and biological activity of new ethacrynic acid (<b>EA</b>) analogs (<b>6-10</b>) obtained by the double modulation of the carboxylic acid moiety and the aromatic ring with the aim to increase the chemical reactivity of Michael acceptor of <b>EA</b>. All obtained compounds were characterized by <sup>1</sup>H and <sup>13</sup>C NMR, IR, and high-resolution mass spectrometry. The antiproliferative activity was evaluated in vitro using MMT test ...[more]