Ontology highlight
ABSTRACT:
SUBMITTER: Zetterberg H
PROVIDER: S-EPMC9866262 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Zetterberg Henrik H Teunissen Charlotte C van Swieten John J Kuhle Jens J Boxer Adam A Rohrer Jonathan D JD Mitic Laura L Nicholson Alexandra M AM Pearlman Rodney R McCaughey Stella Mayo SM Tatton Nadine N
Brain communications 20221126 1
Genetic frontotemporal lobar degeneration caused by autosomal dominant gene mutations provides an opportunity for targeted drug development in a highly complex and clinically heterogeneous dementia. These neurodegenerative disorders can affect adults in their middle years, progress quickly relative to other dementias, are uniformly fatal and have no approved disease-modifying treatments. Frontotemporal dementia, caused by mutations in the <i>GRN</i> gene which encodes the protein progranulin, is ...[more]