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Stimuli-responsive injectable chitosan-based hydrogels for controlled drug delivery systems.

ABSTRACT: In the last decade, injectable hydrogels have attracted a lot of attention due to their excellent functional properties in the field of drug delivery for precise, non-invasive and focused tissue locations. Therefore, designing drug delivery systems (DDS) responsive to hydrogel stimuli to release a drug to an external stimulus with various advantages, can be very challenging. Due to their biocompatibility, mucosal adhesion, and hemostatic activity, chitosan (Chitosan)-based hydrogels offer a lot of potential for tissue engineering and drug delivery. It can be difficult to manage the structure of these stimuli-responsive CS hydrogels or they may require additional crosslinking agents, such as hydrogels with dual pH and thermo-responsiveness. Therefore, it is crucial to create these hydrogels for medicinal applications.

SUBMITTER: Garshasbi H

PROVIDER: S-EPMC9869377 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Stimuli-responsive injectable chitosan-based hydrogels for controlled drug delivery systems.

Garshasbi Hamidreza H Salehi Saba S Naghib Seyed Morteza SM Ghorbanzadeh Sadegh S Zhang Wei W

Frontiers in bioengineering and biotechnology 20230106

In the last decade, injectable hydrogels have attracted a lot of attention due to their excellent functional properties in the field of drug delivery for precise, non-invasive and focused tissue locations. Therefore, designing drug delivery systems (DDS) responsive to hydrogel stimuli to release a drug to an external stimulus with various advantages, can be very challenging. Due to their biocompatibility, mucosal adhesion, and hemostatic activity, chitosan (Chitosan)-based hydrogels offer a lot ...[more]

PMID: 36698640

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