Dataset Information

SARS-CoV-2 infection predicts larger infarct volume in patients with acute ischemic stroke.

ABSTRACT:

Background and purpose

Acute ischemic stroke (AIS) is a fearful complication of Coronavirus Disease-2019 (COVID-19). Aims of this study were to compare clinical/radiological characteristics, endothelial and coagulation dysfunction between acute ischemic stroke (AIS) patients with and without COVID-19 and to investigate if and how the SARS-CoV-2 spike protein (SP) was implicated in triggering platelet activation.

Methods

We enrolled AIS patients with COVID-19 within 12 h from onset and compared them with an age- and sex-matched cohort of AIS controls without COVID-19. Neuroimaging studies were performed within 24 h. Blood samples were collected in a subset of 10 patients.

Results

Of 39 AIS patients, 22 had COVID-19 and 17 did not. Admission levels of Factor VIII and von Willebrand factor antigen were significantly higher in COVID-19 patients and positively correlated with the infarct volume. In multivariate linear regression analyses, COVID-19 was an independent predictor of infarct volume (B 20.318, Beta 0.576, 95%CI 6.077-34.559; p = 0.011). SP was found in serum of 2 of the 10 examined COVID-19 patients. Platelets from healthy donors showed a similar degree of procoagulant activation induced by COVID-19 and non-COVID-19 patients' sera. The anti-SP and anti-FcγRIIA blocking antibodies had no effect in modulating platelet activity in both groups.

Conclusions

SARS-CoV-2 infection seems to play a major role in endothelium activation and infarct volume extension during AIS.

SUBMITTER: De Michele M

PROVIDER: S-EPMC9871539 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

SARS-CoV-2 infection predicts larger infarct volume in patients with acute ischemic stroke.

De Michele Manuela M Lorenzano Svetlana S Piscopo Paola P Rivabene Roberto R Crestini Alessio A Chistolini Antonio A Stefanini Lucia L Pulcinelli Fabio M FM Berto Irene I Campagna Roberta R Amisano Paolo P Iacobucci Marta M Cirelli Carlo C Falcou Anne A Nicolini Ettore E Schiavo Oscar G OG Toni Danilo D

Frontiers in cardiovascular medicine 20230110

<h4>Background and purpose</h4>Acute ischemic stroke (AIS) is a fearful complication of Coronavirus Disease-2019 (COVID-19). Aims of this study were to compare clinical/radiological characteristics, endothelial and coagulation dysfunction between acute ischemic stroke (AIS) patients with and without COVID-19 and to investigate if and how the SARS-CoV-2 spike protein (SP) was implicated in triggering platelet activation.<h4>Methods</h4>We enrolled AIS patients with COVID-19 within 12 h from onset ...[more]

PMID: 36704480

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Project description:BackgroundSerum vascular endothelial growth factor (VEGF) and infarct volume detected by brain imaging have been associated with stroke outcome. However, the relationship of these two variables with post-stroke cognitive impairment (PSCI) remains unclear. We aimed to investigate the association between acute serum VEGF levels and infarct volume with PSCI in ischemic stroke patients.MethodsFifty-six first-ever ischemic stroke patients who were hospitalized in Dr. Sardjito General Hospital Yogyakarta, Indonesia were prospectively recruited. Serum VEGF level was taken on day 5 of stroke onset and measured by ELISA. Infarct volume was calculated manually from head CT scan by expert radiologist. PSCI was assessed after 3 months follow up by using Montreal Cognitive Assessment-Indonesian version (MoCA-INA). We performed a ROC curve analysis to determine the cut-off point of VEGF level and infarct volume. Multivariate logistic regression analysis was performed to measure the contribution of VEGF level and infarct volume to PSCI after controlling covariates (demographic and clinical data).ResultsThe mean age of PSCI and non-PSCI patients was 61.63% ± 8.47 years and 58.67% ± 9.01 years, respectively (p = 0.221). No differences observed for vascular risk factors, infarct location, and NIHSS in both groups. Multivariate logistic regression showed that patients with higher VEGF level alone (≥519.8 pg/ml) were 4.99 times more likely to have PSCI than those with lower VEGF level (OR = 4.99, 95% CI = 1.01-24.7, p = 0.048). In addition, patients with larger infarct volume alone (≥0.054 ml) were also more frequently associated with PSCI (OR = 7.71, 95% CI = 1.39-42.91, p = 0.019).ConclusionsAcute ischemic stroke patients with higher serum VEGF level (≥519.8 pg/ml) and larger infarct volume (≥0.054 ml) were more likely to have PSCI 3 months after stroke. These findings may contribute to predict PSCI earlier and thus better prevention strategy could be made.

Dataset Information

SARS-CoV-2 infection predicts larger infarct volume in patients with acute ischemic stroke.

Background and purpose

Methods

Results

Conclusions

Publications

SARS-CoV-2 infection predicts larger infarct volume in patients with acute ischemic stroke.

Similar Datasets

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