Ontology highlight
ABSTRACT:
SUBMITTER: Imanishi T
PROVIDER: S-EPMC9876550 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Imanishi Takayuki T Unno Midori M Yoneda Natsumi N Motomura Yasutaka Y Mochizuki Miho M Sasaki Takaharu T Pasparakis Manolis M Saito Takashi T
Science advances 20230125 4
Receptor-interacting protein kinase 1 (RIPK1) regulates cell death and inflammation. Here, we show that T cell-specific RIPK1 deficiency in mice leads to the premature senescence of T cells and induces various age-related diseases, resulting in premature death. RIPK1 deficiency causes higher basal activation of mTORC1 (mechanistic target of rapamycin complex 1) that drives enhanced cytokine production, induction of senescence-related genes, and increased activation of caspase-3/7, which are rest ...[more]