Ontology highlight
ABSTRACT:
SUBMITTER: Remes C
PROVIDER: S-EPMC9881170 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Remes Cristina C Khawaja Anas A Pearce Sarah F SF Dinan Adam M AM Gopalakrishna Shreekara S Cipullo Miriam M Kyriakidis Vasileios V Zhang Jingdian J Dopico Xaquin Castro XC Yukhnovets Olessya O Atanassov Ilian I Firth Andrew E AE Cooperman Barry B Rorbach Joanna J
Nucleic acids research 20230101 2
The synthesis of mitochondrial OXPHOS complexes is central to cellular metabolism, yet many molecular details of mitochondrial translation remain elusive. It has been commonly held view that translation initiation in human mitochondria proceeded in a manner similar to bacterial systems, with the mitoribosomal small subunit bound to the initiation factors, mtIF2 and mtIF3, along with initiator tRNA and an mRNA. However, unlike in bacteria, most human mitochondrial mRNAs lack 5' leader sequences t ...[more]