Ontology highlight
ABSTRACT:
SUBMITTER: Yan W
PROVIDER: S-EPMC9882066 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Yan Wei W Steele Nina G NG Kemp Samantha B SB Menjivar Rosa E RE Du Wenting W Carpenter Eileen S ES Donahue Katelyn L KL Brown Kristee L KL Irizarry-Negron Valerie V Yang Sion S Burns William R WR Zhang Yaqing Y di Magliano Marina Pasca MP Bednar Filip F
bioRxiv : the preprint server for biology 20230113
Pancreatic ductal adenocarcinoma (PDA) continues to have a dismal prognosis. The poor survival of patients with PDA has been attributed to a high rate of early metastasis and low efficacy of current therapies, which partly result from its complex immunosuppressive tumor microenvironment. Previous studies from our group and others have shown that tumor-associated macrophages (TAMs) are instrumental in maintaining immunosuppression in PDA. Here, we explored the role of Notch signaling, a key regul ...[more]