Ontology highlight
ABSTRACT:
SUBMITTER: Ho KH
PROVIDER: S-EPMC9883185 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Ho Kung-Hsien KH Jayathilake Anissa A Yagan Mahircan M Nour Aisha A Osipovich Anna B AB Magnuson Mark A MA Gu Guoqiang G Kaverina Irina I
iScience 20230107 2
Glucose stimulation induces the remodeling of microtubules, which potentiates insulin secretion in pancreatic β-cells. CAMSAP2 binds to microtubule minus ends to stabilize microtubules in several cultured clonal cells. Here, we report that the knockdown of CAMSAP2 in primary β-cells reduces total insulin content and attenuates GSIS without affecting the releasability of insulin vesicles. Surprisingly, CAMSAP2 knockdown does not change microtubule stability. Unlike in cultured insulinoma cells, C ...[more]