Dataset Information

Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series.

ABSTRACT:

Background

According to the World Health Organization, the global burden of nosocomial infections is poorly characterized as surveillance systems are lacking. Nosocomial infections occur at higher rates in low- and lower-middle-income countries (LMICs) than in high-income countries (HICs). Current global RSV burden estimates are largely based on community-acquired infection. We aimed to characterize children with nosocomial RSV-related mortality and to understand the potential impact of RSV immunization strategies.

Materials

RSV GOLD is a global registry of children younger than 5 years who died with laboratory-confirmed RSV infection. We compared clinical and demographic characteristics of children with nosocomial and community-acquired RSV in-hospital mortality.

Results

We included 231 nosocomial and 931 community-acquired RSV-related in-hospital from deaths from 65 countries. Age at death was similar for both groups (5.4 vs. 6 months). A higher proportion of nosocomial deaths had comorbidities (87% vs. 57%; P < 0.001) or was born preterm (46% vs. 24%; P < 0.001) than community-acquired deaths. The proportion of nosocomial deaths among all RSV deaths was lower in LMICs than in upper-middle-income countries (UMICs) and HICs (12% vs. 18% and 26%, respectively).

Conclusions

This is the first global case series of children dying with nosocomial RSV infection. Future infant-targeted immunization strategies could prevent the majority of nosocomial RSV-related deaths. Although nosocomial RSV deaths are expected to occur at highest rates in LMICs, the number of reported nosocomial RSV deaths was low in these countries. Hospital-based surveillance is needed to capture the full burden of nosocomial RSV mortality in LMICs.

SUBMITTER: Lowensteyn YN

PROVIDER: S-EPMC9891274 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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Publications

Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series.

Löwensteyn Yvette N YN Willemsen Joukje E JE Mazur Natalie I NI Scheltema Nienke M NM van Haastregt Nynke C J NCJ Buuren Amber A A Ten AAAT van Roessel Ichelle I Scheepmaker Dunja D Nair Harish H van de Ven Peter M PM Bont Louis J LJ

The Pediatric infectious disease journal 20221108 1

<h4>Background</h4>According to the World Health Organization, the global burden of nosocomial infections is poorly characterized as surveillance systems are lacking. Nosocomial infections occur at higher rates in low- and lower-middle-income countries (LMICs) than in high-income countries (HICs). Current global RSV burden estimates are largely based on community-acquired infection. We aimed to characterize children with nosocomial RSV-related mortality and to understand the potential impact of ...[more]

PMID: 36476518

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Dataset Information

Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series.

Background

Materials

Results

Conclusions

Publications

Nosocomial RSV-related In-hospital Mortality in Children <5 Years: A Global Case Series.

Similar Datasets

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