Dataset Information

The maternal prenatal and offspring early-life gut microbiome of childhood asthma phenotypes.

ABSTRACT:

Background

The infant fecal microbiome is known to impact subsequent asthma risk, but the environmental exposures impacting this association, the role of the maternal microbiome, and how the microbiome impacts different childhood asthma phenotypes are unknown.

Methods

Our objective was to identify associations between features of the prenatal and early-life fecal microbiomes and child asthma phenotypes. We analyzed fecal 16 s rRNA microbiome profiling and fecal metabolomic profiling from stool samples collected from mothers during the third trimester of pregnancy (n = 120) and offspring at ages 3-6 months (n = 265), 1 (n = 436) and 3 years (n = 506) in a total of 657 mother-child pairs participating in the Vitamin D Antenatal Asthma Reduction Trial. We used clinical data from birth to age 6 years to characterize subjects with asthma as having early, transient or active asthma phenotypes. In addition to identifying specific genera that were robustly associated with asthma phenotypes in multiple covariate-adjusted models, we clustered subjects by their longitudinal microbiome composition and sought associations between fecal metabolites and relevant microbiome and clinical features.

Results

Seven maternal and two infant fecal microbial taxa were robustly associated with at least one asthma phenotype, and a longitudinal gut microenvironment profile was associated with early asthma (Fisher exact test p = .03). Though mode of delivery was not directly associated with asthma, we found substantial evidence for a pathway whereby cesarean section reduces fecal Bacteroides and microbial sphingolipids, increasing susceptibility to early asthma.

Conclusion

Overall, our results suggest that the early-life, including prenatal, fecal microbiome modifies risk of asthma, especially asthma with onset by age 3 years.

SUBMITTER: Lee-Sarwar KA

PROVIDER: S-EPMC9892205 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Publications

The maternal prenatal and offspring early-life gut microbiome of childhood asthma phenotypes.

Lee-Sarwar Kathleen A KA Chen Yih-Chieh YC Chen Yuan Yao YY Kozyrskyj Anita L AL Mandhane Piush J PJ Turvey Stuart E SE Subbarao Padmaja P Bisgaard Hans H Stokholm Jakob J Chawes Bo B Sørensen Søren J SJ Kelly Rachel S RS Lasky-Su Jessica J Zeiger Robert S RS O'Connor George T GT Sandel Megan T MT Bacharier Leonard B LB Beigelman Avraham A Carey Vincent J VJ Harshfield Benjamin J BJ Laranjo Nancy N Gold Diane R DR Weiss Scott T ST Litonjua Augusto A AA

Allergy 20220924 2

<h4>Background</h4>The infant fecal microbiome is known to impact subsequent asthma risk, but the environmental exposures impacting this association, the role of the maternal microbiome, and how the microbiome impacts different childhood asthma phenotypes are unknown.<h4>Methods</h4>Our objective was to identify associations between features of the prenatal and early-life fecal microbiomes and child asthma phenotypes. We analyzed fecal 16 s rRNA microbiome profiling and fecal metabolomic profili ...[more]

PMID: 36107703

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Project description:The developing immune system and central nervous system in the fetus and child are extremely sensitive to both exogenous and endogenous signals. Early immune system programming, leading to changes that can persist over the life course, has been suggested, and other evidence suggests that immune dysregulation in the early developing brain may play a role in neurodevelopmental disorders such as autism spectrum disorder and schizophrenia. The timing of immune dysregulation with respect to gestational age and neurologic development of the fetus may shape the elicited response. This creates a possible sensitive window of programming or vulnerability. This review will explore the effects of maternal prenatal and infant nutritional status (from conception until early childhood) as well as maternal prenatal stress and anxiety on early programming of immune function, and how this might influence neurodevelopment. We will describe fetal immune system development and maternal-fetal immune interactions to provide a better context for understanding the influence of nutrition and stress on the immune system. Finally, we will discuss the implications for prevention of neurodevelopmental disorders, with a focus on nutrition. Although certain micronutrient supplements have shown to both reduce the risk of neurodevelopmental disorders and enhance fetal immune development, we do not know whether their impact on immune development contributes to the preventive effect on neurodevelopmental disorders. Future studies are needed to elucidate this relationship, which may contribute to a better understanding of preventative mechanisms. Integrating studies of neurodevelopmental disorders and prenatal exposures with the simultaneous evaluation of neural and immune systems will shed light on mechanisms that underlie individual vulnerability or resilience to neurodevelopmental disorders and ultimately contribute to the development of primary preventions and early interventions.

Dataset Information

The maternal prenatal and offspring early-life gut microbiome of childhood asthma phenotypes.

Background

Methods

Results

Conclusion

Publications

The maternal prenatal and offspring early-life gut microbiome of childhood asthma phenotypes.

Similar Datasets

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