Ontology highlight
ABSTRACT:
SUBMITTER: Alarcon Tomas A
PROVIDER: S-EPMC9892211 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Alarcon Tomas Ana A Fein Joshua A JA Fried Shalev S Flynn Jessica R JR Devlin Sean M SM Fingrut Warren B WB Anagnostou Theodora T Alperovich Anna A Shah Nishi N Fraint Ellen E Lin Richard J RJ Scordo Michael M Batlevi Connie Lee CL Besser Michal J MJ Dahi Parastoo B PB Danylesko Ivetta I Giralt Sergio S Imber Brandon S BS Jacoby Elad E Kedmi Meirav M Nagler Arnon A Palomba M Lia ML Roshal Mikhail M Salles Gilles A GA Sauter Craig C Shem-Tov Noga N Shimoni Avichai A Yahalom Joachim J Yerushalmi Ronit R Shah Gunjan L GL Avigdor Abraham A Perales Miguel-Angel MA Shouval Roni R
Leukemia 20221105 1
Persistence or recurrence of large B-cell lymphoma after CD19-CAR-T is common, yet data guiding management are limited. We describe outcomes and features following CAR-T treatment failure. Of 305 adults who received CD19-CAR-T, 182 experienced disease recurrence or progression (1-year cumulative incidence 63% [95%CI: 57-69]). Of 52 post-CAR-T biopsies evaluated by flow cytometry, 49 (94%) expressed CD19. Subsequent anti-cancer treatment was administered in 135/182 (74%) patients with CAR-T treat ...[more]