Ontology highlight
ABSTRACT:
SUBMITTER: Julia E
PROVIDER: S-EPMC9892962 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Future oncology (London, England) 20210312 17
Epigenetic alterations are major drivers of follicular lymphomagenesis, and these alterations are frequently caused by mutations in or upregulation of <i>EZH2</i>, a histone methyltransferase responsible for PRC2-mediated gene repression. EZH2 hyperactivation increases proliferation of B cells and prevents them from exiting the germinal center, favoring lymphomagenesis. The first FDA-approved EZH2 inhibitor is tazemetostat, which is orally available and targets both mutant and wild-type forms of ...[more]