Ontology highlight
ABSTRACT:
SUBMITTER: Han Y
PROVIDER: S-EPMC9894649 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Han Yingying Y Villarreal-Ponce Alvaro A Gutierrez Guadalupe G Nguyen Quy Q Sun Peng P Wu Ting T Sui Benjamin B Berx Geert G Brabletz Thomas T Kessenbrock Kai K Zeng Yi Arial YA Watanabe Kazuhide K Dai Xing X
Cell reports 20220101 2
Maintenance of undifferentiated, long-lived, and often quiescent stem cells in the basal compartment is important for homeostasis and regeneration of multiple epithelial tissues, but the molecular mechanisms that coordinately control basal cell fate and stem cell quiescence are elusive. Here, we report an epithelium-intrinsic requirement for Zeb1, a core transcriptional inducer of epithelial-to-mesenchymal transition, for mammary epithelial ductal side branching and for basal cell regenerative c ...[more]