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Adoptive tumor infiltrating lymphocytes cell therapy for cervical cancer.

ABSTRACT: Cervical cancer is one of the most common malignancies among females. As a virus-related cancer, cervical cancer has attracted a lot of attention to develop virus-targeted immune therapy, including vaccine and adoptive immune cell therapy (ACT). Adoptive tumor infiltrating lymphocytes (TILs) cell therapy has been found to be able to control advanced disease progression in some cervical cancer patients who have received several lines of treatment in a pilot clinical trial. In addition, sustainable therapeutic effect has been identified in some cases. The safety risks of TIL therapy for patients are minimal or at least manageable. In this review, we focused on the versatility of TILs and tried to summarize potential strategies to improve the therapeutic effect of TILs and discuss related perspectives.

SUBMITTER: Zhu Y

PROVIDER: S-EPMC9897649 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Adoptive tumor infiltrating lymphocytes cell therapy for cervical cancer.

Zhu Yahui Y Zhou Jing J Zhu Lijing L Hu Wenjing W Liu Baorui B Xie Li L

Human vaccines & immunotherapeutics 20220425 5

Cervical cancer is one of the most common malignancies among females. As a virus-related cancer, cervical cancer has attracted a lot of attention to develop virus-targeted immune therapy, including vaccine and adoptive immune cell therapy (ACT). Adoptive tumor infiltrating lymphocytes (TILs) cell therapy has been found to be able to control advanced disease progression in some cervical cancer patients who have received several lines of treatment in a pilot clinical trial. In addition, sustainabl ...[more]

PMID: 35468048

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Adoptive Cell Therapy with Tumor-Infiltrating Lymphocytes in Advanced Melanoma Patients.

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| S-EPMC5883986 | biostudies-literature

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| S-EPMC8353905 | biostudies-literature

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