Ontology highlight
ABSTRACT:
SUBMITTER: He X
PROVIDER: S-EPMC9898031 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
He Xiaoxiao X Xu Yilu Y Huang Dan D Yu Zhuo Z Yu Jing J Xie Li L Liu Ligen L Yu Ye Y Chen Chiqi C Wan Jiangbo J Zhang Yaping Y Zheng Junke J
Leukemia 20221123 2
How bone marrow niches regulate leukemogenic activities of leukemia-initiating cells (LICs) is unclear. The present study revealed that the metabolic niche component, ATP, efficiently induced ion influx in LICs through its ligand-gated ion channel, P2X1. P2X1 deletion impaired LIC self-renewal capacities and resulted in an approximately 8-fold decrease in functional LIC numbers in a murine acute myeloid leukemia (AML) model without affecting normal hematopoiesis. P2X1 phosphorylation at specific ...[more]