L3MBTL3 is induced by HIF-1α and fine tunes the HIF-1α degradation under hypoxia in vitro.
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ABSTRACT:
SUBMITTER: Wang M
PROVIDER: S-EPMC9898070 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
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L3MBTL3 is induced by HIF-1α and fine tunes the HIF-1α degradation under hypoxia in vitro.
Wang Mengdong M Wang Di D Lang Yue Y Shao Anwen A Zhang Rui R Tang Jun J Lai Dongming D Xiao Chenglu C
Heliyon 20230124 2
HIF-1α plays a crucial part in hypoxia response by transcriptionally upregulating genes to adapt the hypoxic condition. HIF-1α is under severe cellular control as its exceptional activation is always associated with tumorigenesis and tumor progression. Here, we report L3MBTL3 serves as a novel negative regulator of HIF-1α. It is upregulated during hypoxia and acts as a transcriptional target of HIF-1α. In the nuclei, L3MBTL3 makes an interaction with HIF-1α and promotes its ubiquitination and de ...[more]
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