Dataset Information

Longitudinal association between adiposity changes and lung function deterioration.

ABSTRACT:

Background

The longitudinal relationship between adiposity and lung function is controversial. We aimed to investigate the long-term association between adiposity changes and lung function in a middle-aged general Asian population.

Methods

In total, 5011 participants (average age, 54 years; 45% men) were enrolled from a community-based prospective cohort. During the follow-up period (median 8 years), both spirometry and bio-electrical impedance analysis were performed biannually. Individual slopes of the fat mass index (FMI; fat mass divided by the square of height in meters) and waist-to-hip ratio (WHR) were calculated using linear regression analysis. Multivariate linear mixed regression analysis was used to determine the long-term association between adiposity changes and lung function.

Results

The FMI was inversely associated with forced vital capacity (FVC) (estimated: - 31.8 mL in men, - 27.8 mL in women) and forced expiratory volume in 1 s (FEV₁) (estimated: - 38.2 mL in men, - 17.8 mL in women) after adjusting for baseline age, height, residential area, smoking exposure (pack-years, men only), initial adiposity indices, and baseline lung function. The WHR was also inversely associated with FVC (estimated = - 1242.2 mL) and FEV₁ (estimated = - 849.8 mL) in men. The WHR-increased group showed a more rapid decline in lung function than the WHR-decreased group in both the fat-gain and fat-loss groups.

Conclusion

Adiposity was associated with the long-term impairment of lung function. Central obesity was the main driver of lung function impairment in the middle-aged general Asian population, regardless of fat mass changes.

SUBMITTER: Park Y

PROVIDER: S-EPMC9903501 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature

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Publications

Longitudinal association between adiposity changes and lung function deterioration.

Park Youngmok Y Kim Jiyoung J Kim Young Sam YS Leem Ah Young AY Jo Jinyeon J Chung Kyungsoo K Park Moo Suk MS Won Sungho S Jung Ji Ye JY

Respiratory research 20230207 1

<h4>Background</h4>The longitudinal relationship between adiposity and lung function is controversial. We aimed to investigate the long-term association between adiposity changes and lung function in a middle-aged general Asian population.<h4>Methods</h4>In total, 5011 participants (average age, 54 years; 45% men) were enrolled from a community-based prospective cohort. During the follow-up period (median 8 years), both spirometry and bio-electrical impedance analysis were performed biannually. ...[more]

PMID: 36750832

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Dataset Information

Longitudinal association between adiposity changes and lung function deterioration.

Background

Methods

Results

Conclusion

Publications

Longitudinal association between adiposity changes and lung function deterioration.

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