Unknown

Dataset Information

0

Recent advances in ocular graft-versus-host disease.


ABSTRACT: Ocular graft-versus-host-disease (GVHD) remains a significant clinical complication after allogeneic hematopoietic stem cell transplantation. Impaired visual function, pain, and other symptoms severely affect affected individuals' quality of life. However, the diagnosis of and therapy for ocular GVHD involve a multidisciplinary approach and remain challenging for both hematologists and ophthalmologists, as there are no unified international criteria. Through an exploration of the complex pathogenesis of ocular GVHD, this review comprehensively summarizes the pathogenic mechanism, related tear biomarkers, and clinical characteristics of this disease. Novel therapies based on the mechanisms are also discussed to provide insights into the ocular GVHD treatment.

SUBMITTER: Cheng X 

PROVIDER: S-EPMC9905686 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

altmetric image

Publications

Recent advances in ocular graft-versus-host disease.

Cheng Xianjing X   Huang Ruihao R   Huang Shiqin S   Fan Wei W   Yuan Rongdi R   Wang Xiaoqi X   Zhang Xi X  

Frontiers in immunology 20230125


Ocular graft-versus-host-disease (GVHD) remains a significant clinical complication after allogeneic hematopoietic stem cell transplantation. Impaired visual function, pain, and other symptoms severely affect affected individuals' quality of life. However, the diagnosis of and therapy for ocular GVHD involve a multidisciplinary approach and remain challenging for both hematologists and ophthalmologists, as there are no unified international criteria. Through an exploration of the complex pathoge  ...[more]

Similar Datasets

| S-EPMC10009889 | biostudies-literature
| S-EPMC2084257 | biostudies-literature
| S-EPMC8546182 | biostudies-literature
| S-EPMC4604037 | biostudies-literature
| S-EPMC3294118 | biostudies-literature
| S-EPMC3780546 | biostudies-literature
| S-EPMC8085043 | biostudies-literature
| S-EPMC7604566 | biostudies-literature
| S-EPMC2789626 | biostudies-literature
| S-EPMC7442883 | biostudies-literature