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ABSTRACT:
SUBMITTER: Lysak DH
PROVIDER: S-EPMC9906653 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Lysak Daniel H DH Kock Flavio V C FVC Mamone Salvatore S Soong Ronald R Glöggler Stefan S Simpson Andre J AJ
Chemical science 20230109 6
In line with recent paradigm shifts in toxicity testing, <i>in vivo</i> nuclear magnetic resonance (NMR) is a powerful tool for studying the biological impacts and perturbations caused by toxicants in living organisms. However, despite the excellent molecular insights that can be obtained through this technique, <i>in vivo</i> NMR applications are hampered by considerable experimental challenges such as poor line shape and spectral overlap. Here, we demonstrate the application of singlet-filtere ...[more]