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ABSTRACT:
SUBMITTER: Huttunen J
PROVIDER: S-EPMC9906736 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Huttunen Johanna J Kronenberger Thales T Montaser Ahmed B AB Králová Adéla A Terasaki Tetsuya T Poso Antti A Huttunen Kristiina M KM
Molecular pharmaceutics 20230123 2
Membrane transporters are the key determinants of the homeostasis of endogenous compounds in the cells and their exposure to drugs. However, the substrate specificities of distinct transporters can overlap. In the present study, the interactions of l-type amino acid transporter 1 (LAT1)-utilizing prodrugs with sodium-coupled neutral amino acid transporter 2 (SNAT2) were explored. The results showed that the cellular uptake of LAT1-utilizing prodrugs into a human breast cancer cell line, MCF-7 ce ...[more]