Dataset Information

Mortality-Associated Risk Factors in Hospitalized COVID-19 Patients in Japan: Findings of the CLOT-COVID Study.

ABSTRACT:

Background

Reports of mortality-associated risk factors in patients with coronavirus disease (COVID-19) are limited.

Methods

We evaluated the clinical features that were associated with mortality among patients who died during hospitalization (N=158) and those who were alive at discharge (N=2,736) from the large-scale, multicenter, retrospective, observational cohort CLOT-COVID study enrolled consecutively hospitalized COVID-19 patients from 16 centers in Japan from April to September 2021. Data from 2,894 hospitalized COVID-19 participants of the CLOT-COVID study were analyzed in this study.

Results

Patients who died were older (71.1 years versus 51.6 years, P<0.001), had higher median D-dimer values on admission (1.7 μg/mL versus 0.8 μg/mL, P<0.001), and had more comorbidities. On admission, the patients who died had more severe COVID-19 than did those who survived (mild: 16% versus 63%, moderate: 47% versus 31%, and severe: 37% versus 6.2%, P<0.001). In patients who died, the incidence of thrombosis and major bleeding during hospitalization was significantly higher than that in those who survived (thrombosis: 8.2% vs. 1.5%, P<0.001; major bleeding: 12.7% vs. 1.4%, P<0.001). Multivariable logistic regression analysis revealed that age >70 years, high D-dimer values on admission, heart disease, active cancer, higher COVID-19 severity on admission, and development of major bleeding during hospitalization were independently associated with a higher mortality risk.

Conclusions

This large-scale observational study in Japan identified several independent risk factors for mortality in hospitalized patients with COVID-19 that could facilitate appropriate risk stratification of patients with COVID-19.

SUBMITTER: Takeyama M

PROVIDER: S-EPMC9909175 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Publications

Mortality-associated Risk Factors in Hospitalized COVID-19 Patients in Japan: Findings of the CLOT-COVID Study.

Takeyama Makoto M Yachi Sen S Nishimoto Yuji Y Tsujino Ichizo I Nakamura Junichi J Yamamoto Naoto N Nakata Hiroko H Ikeda Satoshi S Umetsu Michihisa M Aikawa Shizu S Hayashi Hiroya H Satokawa Hirono H Okuno Yoshinori Y Iwata Eriko E Ogihara Yoshito Y Ikeda Nobutaka N Kondo Akane A Iwai Takehisa T Yamada Norikazu N Ogawa Tomohiro T Kobayashi Takao T Mo Makoto M Yamashita Yugo Y

Journal of epidemiology 20221223 3

<h4>Background</h4>Reports of mortality-associated risk factors in patients with the novel coronavirus disease 2019 (COVID-19) are limited.<h4>Methods</h4>We evaluated the clinical features that were associated with mortality among patients who died during hospitalization (n = 158) and those who were alive at discharge (n = 2,736) from the large-scale, multicenter, retrospective, observational cohort CLOT-COVID study, which enrolled consecutively hospitalized COVID-19 patients from 16 centers in ...[more]

PMID: 36372435

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