Understanding capsid assembly and genome packaging for adeno-associated viruses.
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ABSTRACT:
SUBMITTER: Bennett A
PROVIDER: S-EPMC9910337 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Publications
Understanding capsid assembly and genome packaging for adeno-associated viruses.
Bennett Antonette A Mietzsch Mario M Agbandje-McKenna Mavis M
Future virology 20170608 6
Adeno-associated viruses (AAVs) are promising therapeutic viral vectors. Their capsid is assembled from viral proteins VP1, VP2 and VP3, aided by an assembly-activating protein, followed by replication protein mediated packaging of their 4.7-kb genome with inverted terminal repeats as packaging signals. To aid improvement of AAV vectors, knowledge of viral determinants of successful capsid assembly and genome packaging is important. We review the current knowledge of these two processes and effo ...[more]
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