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Kidney-resident innate-like memory γδ T cells control chronic Staphylococcus aureus infection of mice.


ABSTRACT: γδ T cells are involved in the control of Staphylococcus aureus infection, but their importance in protection compared to other T cells is unclear. We used a mouse model of systemic S. aureus infection associated with high bacterial load and persistence in the kidney. Infection caused fulminant accumulation of γδ T cells in the kidney. Renal γδ T cells acquired tissue residency and were maintained in high numbers during chronic infection. At day 7, up to 50% of renal γδ T cells produced IL-17A in situ and a large fraction of renal γδ T cells remained IL-17A+ during chronic infection. Controlled depletion revealed that γδ T cells restricted renal S. aureus replication in the acute infection and provided protection during chronic renal infection and upon reinfection. Our results demonstrate that kidney-resident γδ T cells are nonredundant in limiting local S. aureus growth during chronic infection and provide enhanced protection against reinfection.

SUBMITTER: Bertram T 

PROVIDER: S-EPMC9910431 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature

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γδ T cells are involved in the control of <i>Staphylococcus aureus</i> infection, but their importance in protection compared to other T cells is unclear. We used a mouse model of systemic <i>S. aureus</i> infection associated with high bacterial load and persistence in the kidney. Infection caused fulminant accumulation of γδ T cells in the kidney. Renal γδ T cells acquired tissue residency and were maintained in high numbers during chronic infection. At day 7, up to 50% of renal γδ T cells pro  ...[more]

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