Ontology highlight
ABSTRACT:
SUBMITTER: Zhang S
PROVIDER: S-EPMC9910597 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Zhang Shaohua S Zhang Qianyu Q Liu Zixin Z Liu Kuo K He Lingjuan L Lui Kathy O KO Wang Lixin L Zhou Bin B
Proceedings of the National Academy of Sciences of the United States of America 20221227 1
Unraveling cell-cell interaction is fundamental to understanding many biological processes. To date, genetic tools for labeling neighboring cells in mammals are not available. Here, we developed a labeling strategy based on the Cre-induced intercellular labeling protein (CILP). Cre-expressing donor cells release a lipid-soluble and membrane-permeable fluorescent protein that is then taken up by recipient cells, enabling fluorescent labeling of neighboring cells. Using CILP, we specifically label ...[more]