Ontology highlight
ABSTRACT:
SUBMITTER: Hull JA
PROVIDER: S-EPMC9911311 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Hull Joshua A JA Mietzsch Mario M Chipman Paul P Strugatsky David D McKenna Robert R
Virology 20211006
Adeno-associated virus (AAV) are classified as non-enveloped ssDNA viruses. However, AAV capsids embedded within exosomes have been observed, and it has been suggested that the AAV membrane associated accessory protein (MAAP) may play a role in envelope-associated AAV (EA-AAV) capsid formation. Here, we observed and selected sufficient homogeneous EA-AAV capsids of AAV2, produced using the Sf9 baculoviral expression system, to determine the cryo-electron microscopy (cryo-EM) structure at 3.14 Å ...[more]